无创呼吸机联合可拉明与纳洛酮治疗AECOPD合并II 型呼吸衰竭临床疗效分析.docVIP

无创呼吸机联合可拉明与纳洛酮治疗AECOPD合并II 型呼吸衰竭临床疗效分析 　　[摘要] 目的 探讨应用无创呼吸机联合可拉明和纳洛酮治疗AECOPD合并II型呼吸衰竭患者的临床疗效。方法 选取该院2011年6月―2012年7月收治的AECOPD合并II型呼吸衰竭患者75例，随机平均分成3组，A组采用（常规治疗+可拉明+纳洛酮），B组（常规治疗+无创呼吸机），C组（常规治疗+无创呼吸机+可拉明+纳洛酮），分别记录患者治疗前和治疗1周的血气指标，记录三组患者治疗后的气管插管例数、住院天数和无创通气总时间。结果 B组、C组治疗后与治疗前比较血气各指标差异有统计学意义（P0.05），治疗后三组组间血气指标比较差异有统计学意义（P0.05），C组与A、B组比较气管插管率和住院天数差异有统计学意义（P0.05），C组与B组比较无创通气总时间差异有统计学意义（P0.05）。结论 无创呼吸机联合可拉明和纳洛酮治疗更能有效改善AECOPD合并II型呼吸衰竭患者的血气状况，改善住院状况，值得临床推广应用。 　　[关键词] 无创呼吸机；可拉明；纳洛酮；慢性阻塞性肺疾病；II型呼吸衰竭 　　[中图分类号] R563.9；R563.8 [文献标识码] A [文章编号] 1674-0742（2015）05（c）-0071-02 　　[Abstract] Objective To explore the application of noninvasive ventilation combined with Coramine and naloxone in treatment for AECOPD complicated by II type respiratory failure. Methods AECOPD with II type respiratory failure patients with 75 cases， from 2011 June to 2012 July in ur hospital were randomly divided into 3 groups， group A （conventional therapy + Coramine + naloxone）， B group （ conventional therapy + noninvasive ventilator ）， C group （conventional therapy + Coramine + noninvasive ventilator + naloxone ）， were recorded before treatment and 1 weeks blood gas change and comparative analysis， statistics of the three groups after treatment of tracheal intubation patients number， length of hospital stay and noninvasive ventilation time. Results In B group and C group before and after treatment， comparison of blood gas indexes has significant difference （P0.05 ）， Blood gas difference among the three groups after treatment group were significantly （P0.05），group C and A， B group tracheal intubation rate and length of hospital stay has significant difference ???P0.05 ）， C group and B group comparison of noninvasive ventilation time had significant difference （P0.05 ）. Conclusion Noninvasive ventilator combined with Coramine and naloxone treatment can more effectively improve the blood gas status of the patients with AECOPD complicated by II type of respiratory failure and their hospitalization， so it is wo