深圳市肥胖青少年血糖血脂状况分析及2型糖尿病与高危者筛查.docVIP

深圳市肥胖青少年血糖血脂状况分析及2型糖尿病与高危者筛查 　　【摘要】 目的 调查深圳地区超重及肥胖青少年血糖、血脂水平及进行2型糖尿病和高危者筛查。方法 2 138例7~15岁学生作为调查对象进行身高、体质量测量，筛选出201例自愿接受调查的肥胖者进行采集空腹肘静脉血测定血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)和空腹血糖(FPG)及口服葡萄糖耐量试验,测定各项指标。结果 正常、超重、肥胖三组间TG，HDL-C，LDL-C差异均有统计学意义(P0．01)。FPG，TG，HDL-C，LDL-C的异常检出率在不同体型组间差异均有统计学意义(P0．05)。肥胖组的2 h 血糖显著高于超重组和正常组,且糖代谢异常的发生率显著高于另两组(P0.001)。本调查共发现2 型糖尿病1例,糖耐量异常(IGT) 11 例。结论 超重和肥胖青少年较体质量正常者存在明显的血糖和血脂异常。应加强超重和肥胖青少年血糖和血脂检测，并进行综合干预。 　　【关键词】 超重；肥胖症；血糖；血脂；糖尿病 　　 　　Studying on glucose, serum lipids level and screening of type 2 diabetes mellitus and those with high risk among children with obese in Shenzhen 　　CHEN Xiao-hui，LIU Wei-qiang. Gongming People’s Hospital of Shenzhen Guangming New District，Guangdong 518106，China 　　【Abstract】 Objective To explore the characteristics of fasting glucose and serum lipids in overweight and obese children and to investigate the incidence of type 2 diabetes mellitus (DM) and those with high risk.Methods Measurements of height and weight among 2 138 children aged 7 to 15 years in Shenzhen were investigated．201 obesity volunteers were choose, and serum total cholesterol(TC)，triglyceride(TG), high density 1ipoprotein cholesterol(HDL-C), fasting plasma glucose (FPG) andOral glucose tolerance test (OGTT)were analyzed. Results There were significant differences in the levels of TG，HDL-C and LDL-C between children with different body types(P0．01).And the abnormal level of FPG，TG，HDL-C，LDL-C were significantly different (P0．05).The levels of 2 h PG and abnormal glucose metabolic in obesity group were higher than those in overweight and normal groups. One cases with type 2DM, 11 with impaired glucose tolerance (IGT) were found. Conclusion Overweight and obese children have abnormal fasting glucose and serum lipids level compared with normal children. The prevention for obesity and controlling fasting glucose and serum lipids should be started in school-aged children in order to reduce the incidence of disease. 　　【Key words