大动脉硬度检测与-LJ hospital课件.ppt

Relationships between PWV corrected for age, MAP, and gender with hs-CRP (top), IL-6 (middle), and TNF-[alpha] (bottom) in 78 untreated patients with essential hypertension. Arterial Stiffness Is Related to Systemic Inflammation in Essential Hypertension. Hypertension. 46(5):1118-1122, November 2005 Aortic pulse wave velocity as a marker of cardiovascular disease in subjects over 70 years old Sylvie Meaumea, Annie Rudnichie, Antony Lyncha et al. Journal of Hypertension 2001, Vol 19 No 5 CAD人群与健康人群的PWV值 Ｐ＜0.001 PWV(cm/sec) 2500 1,669 1,336 2000 1500 1000 500 0 CAD群 (n=173) 健康群 (n=183) Increased brachial-ankle pulse wave velocity is associated with impaired endothelial function in patients with coronary artery disease Tao Jun，et al. Chin Med J 2006;119(22):1866-1870 Non-invasive measures of pulse wave velocity correlate with coronary arterial plaque load in humans Andrew L. McLeoda,b, Neal G. Urenb et al. Journal of Hypertension 2004, Vol 22 No 2 Prognostic Value of Aortic Pulse Wave Velocity as Index of Arterial Stiffness in the General Population Circulation. 2006;113:664-670. Elevated Aortic Pulse Wave Velocity, a Marker of Arterial Stiffness, Predicts cardiovascular events in well-functioning older adults Circulation. 2005;111:3384-3390. 血管硬化患者生存率低下 対象者：末期腎疾患患者２４１名　（試験開始時平均年齢５１．５歳） 评估：140月后的生存率 Blacher J; Impact of aortic stiffness on survival in endstage renal disease. Circulation, 99: 2434-2439; 1999） 危险因素和baPWV、cfPWV Kezhu SUN,The relation of pulse wave velocities measured by oscillometric and tonometric methods and clinical application studies. Jpn.J.Appl.Physiol.,Vol.32,No2,2002　より引用 ＊：p＜0.05，　＊＊：p＜0.001 危险因素：年龄＞６５、男性、肥胖、吸烟、饮酒、高血糖、高血圧、高脂血症 Aortic stiffness Is an Independent Predictor of Progression to Hypertension in Nonhypertensive Subjects Arterial stiffness 动脉壁硬化 　 　　动脉的僵硬度是血压正常者进展为高血压的独立预测因素 Hypertension.2005;45:426-431 高血圧 800 1000 1200 1400 1600 1800 2000 2200 0 5 10 15 20 25 30 35 40 45 50 日期(天) PWV　(cm/s) 110 120 130 140 150 160 170 1