微针技术.pptVIP

微针技术 Contents 微针技术在经皮给药的应用（2012） 经皮给药系统----微针技术 经皮给药系统(transdermal drug delivery systems，简称 TDDS)是指经皮肤敷贴方式用药，药物经由皮肤吸收进入全身血液循环并达到有效血药浓度、实现疾病治疗或预防的一类制剂。 经皮吸收过程 为什么发展微针技术 皮肤（特别是角质层）严重阻碍药物的透皮吸收，即使在各种促渗剂的作用下，也仅能使部分小分子药物穿过皮肤达到有效的药物浓度，大多数药物，尤其是蛋白类大分子药物，即便是一些剂量低、疗效高的药物，透皮渗透速度也难以满足治疗的需要。 现代促渗技术 微针介绍 利用微针阵列改进皮肤的通透性，通过创造微米尺寸的通道（比分子尺寸大一个数量级），使大分子可以透过皮肤。 微针促渗的原理 Abstract Representation of the skin microanatomy Microneedles made of different materials Schematic representation of the manufacturing of in-plane (right) and out-ofplain (below) microneedles from silicon wafers (upper left) Microneedle geometry Different approaches of drug delivery by hollow and solid microneedles Drug delivery methods via the skin by microneedles Coated microneedles made of metal and polymer Dissolving microneedles made of water-soluble polymers and biodegradable polymers Hollow microneedles made of silicon and polymers advantages and disadvantages of each of these approaches Examples of microneedle-based (trans)dermal delivery of model drugs into the skin Applications of microneedles Delivery to the skin Biotherapeutics Vaccines Blood and interstitialfluid extraction Combination of microneedles and other methods Approved microneedle products The first product was the Dermaroller?, which is a cylindrical roller covered on its surface with solid, metal microneedles that measure 0.2–2.5 mm in length. (/) MicroHyala? was developed as a patch coveredwith dissolving microneedles containing hyaluronic acid that is released in the skin to treat wrinkles. (http://www.cosmed-pharm.co.jp/) Soluvia? is a single hollow microneedle that is 1.5 mm long and is attached to a syringe.(/pharmaceuticals/products/ microinjection.asp) Finally, MicronJet? recently received FDA clearance. (http://www. /content-c.asp?cid=22) 相关链接 微针疫苗/china100438.shtml 微针美容 * * LOGO 基础知识 1 文献解读 2 研究现状 3 相关链接 4 2 3 1 皮肤附属器通道 穿透角质层细胞到达活性表皮 通过角质层细胞间隙到达活性表皮 经皮给药 离子导入 电穿孔 微针 超声导入 优点： 避免了口服给