Telomerase paper幻灯片.pptVIP

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells. Bodner et. al. Science 279, 349-352 (1998) From the laboratory of Woodring E. Wright This paper is an important paper because it shows direct causal relationship between telomerase expression and cellular life-span. Normal human diploid cells have a finite proliferative life-span when placed in culture. After this, they enter a non-proliferative state termed senescence. Replicative senescence is dependent on cumulative cell divisions and not chronologic or metabolic time. Proliferation is limited by a “mitotic cl