白血病诱导分化剂地研究进展.pdfVIP

World Journal of Cancer Research 世界肿瘤研究, 2017, 7(3), 75-80 Published Online July 2017 in Hans. /journal/wjcr /10.12677/wjcr.2017.73012 Research Progress of Leukemia Induced Differentiation Agents Wei Jiang, Xin Deng, Haiying Li, Weiguo Huang* Cancer Institute of University of South China, Hengyang Hunan th th th Received: Jun. 7 , 2017; accepted: Jun. 24 , 2017; published: Jun. 27 , 2017 Abstract Differentiation has the advantages such as highly-selective, low side effect and good curative effect. The further study of differentiation mechanism propels the study and development of treating leukemia by differentiation, and makes it the main method of treating leukemia in the future. In recent years, the differentiation therapy of acute promyelocytic leukemia has become one of the hot points of hematology research, and there has achieved some degree of success in the differen- tiation therapy of leukemia at home and abroad. This paper summarizes the commonly used and molecular mechanism of differentiation induced agents in recent years, such as, dimension of formic acid, arsenic, traditional Chinese medicine, molecular target drugs, demethylating drugs, acetylating drugs and miRNAs. It is helpful to understand the new progress of differentiation. Keywords Leukemia, Differentiation, Differentiation Induced Agent 白血病诱导分化剂的研究进展 江 伟，邓 鑫，李海英，黄卫国* 南华大学肿瘤研究所，湖南 衡阳 收稿日期：2017年6月7 日；录用日期：2017年6月24 日；发布日期：2017年6月27 日 摘 要 诱导分化具有选择性高、副作用小、疗效好等优点。诱导分化机制的研究的深入推动着诱导分化治疗白 *通讯作者。 文章引用: 江伟, 邓鑫, 李海英, 黄卫国. 白血病诱导分化剂的研究进展[J]. 世界肿瘤研究, 2017, 7(3): 75-80. /10.12677/wjcr.2017.73012 江伟 等 血病的研究和发展，使其有望成为将来治疗白血病的主要手段。近年来，急性早幼粒细胞白血病的诱导 分化治疗已成