阿立哌唑、奥氮平、利培酮治疗儿童青少年精神分裂症的效果比较.docVIP

阿立哌唑、奥氮平、利培酮治疗儿童青少年精神分裂症的效果比较 　　[摘要]目的 比较阿立哌唑、奥氮平、利培酮治疗儿童青少年精神分裂症患者的效果。方法 选取西安市精神卫生中心儿少心理科2015年9月～2017年7月的86例住院患者，随机分为阿立哌唑组（29例）、奥氮平组（29例）和利培酮组（28例），分别给予阿立哌唑、奥氮平和利培酮。于治疗前和治疗6周后采用阳性与阴性症状量表（PANSS）和副反应量表（TESS）评价各药物疗效与安全性，并在治疗前后检测患者血清催乳素（PRL）水平。结果 三组患者药物治疗后的PANSS评分均明显下降，差异有统计学意义（P0.05）。奥氮平组和利培酮组治疗后PRL水平均明显升高，差异有统计学意义（P0.05）。结论 三种药物对儿童青少年精神分裂症患者都有显著疗效，奥氮平和利培酮使患者的PRL水平明显升高。 　　[关键词]儿童青少年；精神分裂症；抗精神病药；血清催乳素；阿立哌唑；奥氮平；利培酮 　　[中图分类号] R749.3 [文献标识码] A [文章编号] 1674-4721（2018）2（a）-0008-04 　　[Abstract]Objective To compare the efficacy of Aripiprazole，Olanzapine and Risperidone in the treatment of children and adolescents with schizophrenia.Methods 86 patients with schizophrenia in the Department of Child and Adolescent Psychology in Xi′an Mental Health Center from September 2015 to July 2017 were selected as the research objects，the patients were randomly divided into the Aripiprazole group （29 cases），the Olanzapine group （29 cases） and the Risperidone group （28 cases），Aripiprazole，Olanzapine and Risperidone were given respectively.The efficacy and safety of each drug were evaluated by positive and negative symptoms scale （PANSS） and the test and error support system （TESS） before treatment and after 6 weeks treatment，and serum prolactin （PRL） levels were detected at the same time.Results The PANSS scores of the three groups were significantly lower after the treatment，and the differences were statistically significant （P0.05）.The PRL levels of the Olanzapine group and the Risperidone group were significantly higher after treatment，and the differences were statistically significant （P0.05）.Conclusion Three drugs show similar efficacy in the treatment of schizophrenia in children and adolescents，but Olanzapine and Risperidone treatment can significantly increase serum PRL levels. 　　[Key words]Children and adolescents；Schizophrenia；Ant-ipsychotic drugs；Serum prolactin；Aripiprazole；Olanzapine；Risperidone 　　?和?青少年时期是人体生长发育逐渐成熟的时期，也是自身特质、生活状况和生活态度变化最大的一个时期[1]。近年来，儿童青少年精神分裂症患者的数量急剧增