阿立哌唑和利培酮治疗首发精神分裂症的效果分析.docVIP

阿立哌唑和利培酮治疗首发精神分裂症的效果分析 　　[摘要] 目的 观察阿立哌唑和利培酮治疗首发精神分裂症的临床疗效。 方法 选择2011年1月～2013年1月本院收治的85例首发精神分裂症的患者，随机分为两组，对照组患者给予利培酮治疗，观察组给予阿立哌唑治疗，观察两组患者的临床治疗效果及用药后的不良反应情况。 结果 观察组患者治疗后总有效率为91.30%，对照组治疗后总有效率为92.31%，两组比较，差异无统计学意义（P0.05）；用药后观察组的不良反应发生率为26.09%，对照组为69.23%，两组比较，差异有统计学意义（P0.05）。 结论 阿立哌唑和利培酮治疗首发精神分裂症的临床疗效显著，但阿立哌唑用药后不良反应较少，安全性高，值得临床推广应用。 　　[关键词] 精神分裂症；阿立哌唑；利培酮 　　[中图分类号] R749.3 [文献标识码] A [文章编号] 1674-4721（2015）07（c）-0092-03 　　Effect analysis of aripiprazole and risperidone in the treatment of first-episode schizophrenia 　　YAN Xiao-zhang HE Mei-qun CHEN Wen-ying 　　The Third People′s Hospital of Jian City in Jiangxi Province，Jian 343000，China 　　[Abstract] Objective To study the clinical effect between aripiprazole and risperidone in the treatment of first-episode schizophrenia. Methods 85 cases of first-episode schizophrenia patients in our hospital from January 2011 to January 2013 were randomly divided into two groups.The control group was treated with risperidone while the observation group was given aripiprazole treatment.Then the clinical effect and drug adverse reaction between two groups was compared respectively. Results After the treatment，the total effective rate of the treatment of observation group was 91.30%.While the total effective rate of control group was 92.31%，with no statistical differenc（P0.05）.The incidence of adverse reactions of observation group was 26.09%， while the control group was 69.23%，with statistical difference（P0.05）. Conclusion The clinical effect of aripiprazole and risperidone in the treatment of first-episode schizophrenia is significant，but the adverse reaction of aripiprazole is smaller and the safety is higher.It is worthy of clinical popularization and application. 　　[Key words] Schizophrenia；Aripiprazole；Risperidone 　　精神分裂症是一种涉及到感知觉、思维、情感和行为等多方面障碍及精神活动不协调的临床综合征，常见于青壮年，缓慢或亚急性起病，病情常反复发作，逐渐加重，给患者带来巨大的危害，部分患者最终出现衰退和精神残疾[1]。本研究为观察比较阿立哌唑和利培酮治疗首发精神分裂症的临床疗效，将近3年本院收治的85例首发精神分裂症患者进行分组研究，现将研究结果报道如下。 　　1 资料与方法 　　1.1 一般资料 　　选择2011年1月～20