new approaches to neuroimaging of PML英文.pdfVIP

New Approaches to Neuroimaging of Progressive Multifocal Leukoencephalopathy Alexandra Binnie, HMS III Gillian Lieberman, M.D. Alexandra Binnie, HMSIII Gillian Lieberman, MD What is Progressive Multifocal Leukoencephalopathy (PML)? •A demyelinating disease of the CNS caused by reactivation of the JC virus in immunocompromised patients •PML is typically seen in AIDS patients, transplant recipients, and leukemia patients •80% of normal adults have anti-JC antibodies indicating that exposure to JC virus is almost unive