11-耳内耳聋生物学治疗挑战与实践杨仕明20110806.pptVIP

Delivery of polyplex to cochlea in vivo Polyplex was delivered to cochlea by a micro-invasive surgery. Gelfoam? soaked with polyplex was placed in the round window niche and directly contact round window membrane. 季胺化壳聚糖-β环糊精（CM-β-CD）载基因（Math1）纳米粒基因传递系统的构建 Ren LL, et al. Math1 gene transfer based on the delivery system of quaternized chitosan/ Na- carboxymethyl-β- cyclodextrin nanoparticles. J Nanosci Nanotec 2010.10(11): 7262-7265 （国家发明专利 申请号200910237305.3） 季胺化壳聚糖-β环糊精（CM-β-CD）载基因（Math1）纳米粒基因传递系统的构建 Ren LL, et al. Math1 gene transfer based on the delivery system of quaternized chitosan/