基于肿瘤干细胞的恶性肿瘤靶向治疗策略-中国医学科学院血液学研究所.PDF

中国细胞生物学学报 Chinese Journal of Cell Biology 2015, 37(2): 309–314 DOI: 10.11844/cjcb.2015.02.0214 基于肿瘤干细胞的恶性肿瘤靶向治疗策略 1 2 1* 李姗姗 王 丽 边育红 1 2 ( 天津中医药大学, 天津 300193; 天津市第二人医院, 天津 300192) 摘要 肿瘤干细胞与肿瘤的形成、进展及转移息息相关。针对肿瘤干细胞的靶向治疗已成 为控制并治愈恶性肿瘤的新方法。该文就肿瘤干细胞及基于肿瘤干细胞靶向治疗恶性肿瘤的策略, 如针对其表面标志物、信号传导通路、诱导分化、干预微环境、免疫疗法等加以综述, 为进一步 报 开展针对肿瘤干细胞的靶向疗法提供参考。 关键词 肿瘤; 肿瘤干细胞; 表面标记; 信号通路; 微环境; 免疫治疗 学 Targeted Therapy Strategies of Malignant Tumor Based on Cancer Stem Cells 1 2 1* Li Shanshan , Wang Li , Bian Yuhong 1 2 ( Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; Tianjin Second People’s Hospital, Tianjin 300192, China) 学 Abstract Cancer stem cells (CSCs) are involved in the formation, development and metastasis of tumor. Growing evidences indicated that therapies aiming at CSCs have been proven to be a new method for the treatment of malignant tumors. In order to give reference for the further studies, this paper summarized on CSCs and anti- 物 tumor strategies aiming at CSCs such as CSCs surface markers, signal pathways, differentiation, microenvironment and immunotherapy. Keywords tumor; cancer stem cells; surface markers; signal pathways; microenvironment; immunotherapy 生 肿瘤是一种严重威胁人类身体健康的恶性疾 法进行综述。 病。近年来, 环境污染的加剧、社会压力增大及个 人心理等影响致使肿瘤发病率及死亡率呈明显上升 1 肿瘤干细胞(cancer stem cells, CSCs)