自噬与动脉粥样硬化的关系及中药的干预作用-中国动脉硬化杂志.PDF

736 ISSN 1007鄄3949 Chin J Arterioscler,Vol22,No7,2014 [文章编号]摇 1007鄄3949(2014)22鄄07鄄0736鄄05 ·文献综述 · 自噬与动脉粥样硬化的关系及中药的干预作用 1 2 1 1 于红红 ,吴玛莉 ,冷 泠 摇 综述,田维毅 摇 审校 (1.贵阳中医学院免疫学教研室,2.贵州省疾病预防控制中心慢性病防治研究所,贵州省贵阳市550002) [关键词]摇 自噬;摇 动脉粥样硬化;摇 中药;摇 斑块稳定性 [摘摇 要]摇 自噬是由溶酶体介导的降解胞质内受损的细胞器或蛋白质的代谢过程。 适度的自噬对动脉粥样硬化 具有保护作用,过度的自噬却会导致细胞死亡,不利于斑块的稳定性。 中药能通过多途径、多靶点整合起效防治动 脉粥样硬化,其机制很可能与调控动脉粥样硬化相关细胞自噬有关。 本文就自噬在动脉粥样硬化中的双重作用、 调控自噬对干预动脉粥样硬化的意义、中药对自噬的影响及其在动脉粥样硬化防治中的潜在意义作一综述。 [中图分类号]摇 R363 [文献标识码]摇 A Relationship Between Autophagy and Atherosclerosis and Modulation of Traditional Chinese Medicine 1 2 1 1 YU Hong鄄Hong ,WU Ma鄄Li ,LENG Ling ,and TIAN Wei鄄Yi (1.Department of Immunology,Guiyang College of Traditional Chinese Medicine;2.Research Institute of Chronic Disease Control and Prevention,Guizhou Centerfor Disease Control and Prevention,Guiyang,Guizhou550002,China) [KEY WORDS]摇 Autophagy;摇 Atherosclerosis;摇 Traditional Chinese Medicine;摇 Plaque Stability [ABSTRACT]摇 Autophagy is a metabolic processfor the degradation of damaged organelles or proteins in the cytoplasm via the lysosomal system.摇 A moderate amount of autophagy has a protective effect for atherosclerosis,but excessive auto鄄 phagy can lead to cell deaththat isnot conducivetothe stability of theplaque.摇 Traditional Chinesemedicinecanprevent and treatatherosclerosisthroughmanychannelsandmultipletargetsintegration,whichmechanismisprobablyrelatedtothe regulation of atherosclerosiscell autophagy.摇 Thispaper isto summarizethedualroleof autophagy inatherosclerosis,reg鄄 ulation of autophagy on the significance of intervention of atheroscler