外泌体源性非编码RNA在消化系统恶性肿瘤中的研究进展及展望.PDF

中国癌症杂志 2017年第27卷第4期 《 》 CHINA ONCOLOGY 2017 Vol.27 No.4 297 外泌体源性非编码RNA在消化系统 恶性肿瘤中的研究进展及展望 于淑林 综述 ，陈　震 审校 复旦大学附属肿瘤医院中西医结合科，复旦大学上海医学院肿瘤学系，上海 200032 　　［摘要］　外泌体是纳米级、双层膜的囊泡，由多种细胞分泌，广泛存在于多种体液中。外泌体中含有 RNA和蛋白质等多种活性物质，在细胞物质间和信号转导中起重要作用。非编码RNA具有重要的基因表达调控 功能，在多种肿瘤的发生、发展过程中起重要作用。外泌体源性非编码RNA的研究是目前新的研究热点，现就 外泌体及外泌体源性非编码RNA在消化系统恶性肿瘤中的研究进展进行综述。 　　 ［关键词］　外泌体；非编码RNA；消化系统恶性肿瘤 　　DOI: 10.19401/ki.1007-3639.2017.04.010 　　 中图分类号：R735　　文献标志码：A　　文章编号：1007-3639(2017)04-0297-07 Research progress on exosome-derived non-coding RNA in digestive system malignancy YU Shulin, CHEN Zhen (Department of Integrative Oncology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China) Correspondence to: CHEN Zhen E-mail: zhenczl@ Abstract Exosome is a kind of biological membrane structure at nanometer level. It is secreted by various 　　［ ］ cells and widely distributed in most body fluids. Biological active substances, including non-coding RNAs and proteins, have been identified in the exosomes. Exosome may be involved in cell-to-cell substance transporting and signaling. Non-coding RNAs have important function of regulating gene expression and also play key roles in the occurrence and development of many cancers. Research on exosome-derived non-coding RNA is a new hotspot at present. In this paper, we will review research progress on exosome and exosome-derived non-coding RNA in digestive system malignancy. Key words Exosome; Non-coding RNAs; Digestive system malignancy 　［ ］ lncRNA) RNA(circle RNA circRNA) 　　外泌体是细胞经过“内吞－融合－外排” 和环状 ，