脂肽的自组装特性及其与十二烷基麦芽糖苷的复配-中国科技论文在线.PDFVIP

中国科技论文在线 脂肽的自组装特性及其与十二烷基麦芽糖 苷的复配研究 # 李泉，成磊，于道永，徐海** 5 266580 摘要：HC12-OOHC12HH-COOH C HH-CONH C HHH-CONH 12 2 12 2 MES 20 10 mmol/LpH=6.00.40 mmol/L0.63 mmol/L1.10 mmol/L pH DDM 关键词： 中图分类号：Q54 15 Self-assembly of lipopeptide and its complex with dodecyl maltoside LI Quan, CHENG Lei, YU Daoyong, XU Hai (Center for Bioengineering and Biotechnology, College of Chemical Engineering, China 20 University of Petroleum (East China), Qingdao 266580) Abstract: Three lipopeptide molecules C12HH-COOH, C12HH-CONH2 and C12HHH-CONH2 were synthesized by using histidine (H) and lauric acid (C12-OOH) as materials. Lipopeptide molecular structure contains lauric acid hydrophobic alkane chain, and composed of histidine hydrophilic peptide chain, with the traditional surfactant and peptide surfactant structural features. The surface tension 25 analysis showed that the three lipopeptide molecules were able to exhibit significant surfactant properties in aqueous solution, and the critical micelle concentrations (CMC) in the MES buffer solution (20 mmol/L, pH=6.0) were 0.40 mmol/L, 0.63 mmol/L, 1.10 mmol/L. As the pH value of the