脂蛋白相关磷脂酶A2与2型糖尿病大血管病变相关-第三军医大学学报.DOC

作者简介：商丽娜（1982-），女，老年医学在读研究生，研究方向：老年内分泌糖尿病方向 E-mail:780461484@QQ.com 通讯作者：李华（1960-），女，硕士，主任医师，教授，博士生导师，研究方向：糖尿病及糖尿病血管并发症 ；发表论文60余篇，E-mail:lihuazzu@126.com 研究 方向 脂蛋白相关磷脂酶A2与2型糖尿病大血管病变相关性研究 商 丽 娜 李 华 翟 倩 倩 冯 涛 姜 丹 (郑州大学第一附属医院老年内分泌科，郑州市 450000) 【摘要】目的：观察2型糖尿病（type 2 diabetse mellitus，T2DM）患者血浆脂蛋白相关磷脂酶A2（lipoprotein-associated phospholipase A2,LP-PLA2）水平，探讨其与T2DM大血管并发症的关系及临床意义。方法：选择69 例T2DM患者，分糖尿病合并大血管并发症组，单糖尿病组。同期21名健康体检者作为对照组。应用ELISA检测3组血浆LP-PLA2水平，并进行比较。结果：糖尿病2组LP-PLA2水平与对照组比较差异有统计学意义（p＜0.05）。糖尿病并大血管病变组LP-pLA2水平高于单纯糖尿病组，差异有统计学意义（p＜0.05）。除去混杂因素后LP-PLA2仍与糖尿病血管并发症直接相关（p＜0.05）.结论：LP-PLA2可作为糖尿病的独立危险因素之一，对预测糖尿病血管并发症有一定的意义。 【关键词】 2型糖尿病 ；脂蛋白相关磷脂酶A2；大血管并发症 中图分类号：R587.1 文献标志码：A Correlation of level of lipoprotein-associated phospholipas A2 with type 2 diabetes mellitus and its macrovascular complications SHANG lina, LI hua, ZHAI qianqian, FENG tao，JIANG dan （Department of Endocrinology, The First Affiliated Hospital to Zhengzhou University,Zhengzhou,450000,China） 【Abstract】 Object To explore the correlation between levels of lipoprotein-associated phospholipase A2(LP-PLA2) with 2 diabetes mellitus and its macrovascular complications. Methods A total of 69 subjects were divided into 2 groups ,type 2 diabetes mellitus complicated with macrovascular disease(38 subjects) ,type 2 diabetes mellitus without macrovascular complications(31 subjects).The plasma level of LP-PLA2 were determined by ELISA in these 2 group and another 21 healthy individuals(control group).Results The LP-PLA2 level was significantly higher in patients with type 2 diabetus mellitus than that in control group(p＜0.05), and it was higher in type 2 diabetes mellituscomplicated with macrovascular diseases than that in type 2 diabetes mellitus without macrovascular complications(p＜0.05).Also, removing the confounding factors, LP-PLA2 still directly related to macrovascular complications of diabetes(p＜0.05).Conclusion LP-PLA2 level is one of the independent risk factors for diabetes mellitu