脑钠素和急性心肌梗死患者相关性临床实验分析.docVIP

脑钠素和急性心肌梗死患者相关性临床实验分析 　　【中图分类号】 R522 2 【文献标识码】A 【文章编号】1672－3783(2011)05－0333－01 　　【摘要】目的实验分析血浆脑钠素(BNP)水平与急性心肌梗死(AMI)范围、左室功能及预后的关系方法32例确诊为AMI的患者,入院后进行常规检查且24h后测血浆脑钠素浓度,其中,30例患者行PCI,2例行CABG治疗。1周后检查超声心动图测定左室射血分数(LⅤEF),所有患者随访3个月,观察血浆BNP浓度与AMI的范围、左室功能及预后的关系结果血浆BNP水平与AMI面积呈正相关(P＜0.01),与LVEF呈负相关(P＜0.05),且血浆BNP高的患者心血管事件发生率高(P＜0.05),均有统计学意义结论血浆BNP浓度反映了AMI的严重程度;AMI范围越大,左室功能越差,脑钠素的水平越高,且脑钠素可作为心血管事件的预测指标 　　【关键词】急性心肌梗死；脑钠素；临床实验分析 　　Brain natriuretic meal with acute myocardial infarction patients correlation analysis of clinical trials 　　【Abstract】 ObjectiveExperimental analysis plasma brain natriuretic hormone (BNP) level and acute myocardial infarction (AMI) scope, left entricular function and prognosis of the relationshipMethods32cases were diagnosed as AMI patients, after admission after a routine inspection and measuring 24h plasma brain natriuretic grain concentration, among them, 30 patients underwent CABG PCI, 2 routine treatment. One week after check echocardiography determination of left ventricular ejection fraction (L Ⅴ EF), all patients were followed up for 3 months, observe the plasma BNP concentration with AMI range, and left entricular function and prognosis of the relationshipResultsPlasma BNP levels positively correlated with AMI area (P 0.01), and negatively correlated LVEF (P 0.05), and plasma BNP high cardioascular eents in patients with high (P 0.05), all have statistical significanceConclusions Plasma BNP concentration reflects the severity of AMI, AMI scope, the greater the left entricular function poorer, brain natriuretic element, and the higher the level of brain natriuretic element can be used as cardiovascular events prediction indexes 　　【Key words】Acute myocardial infarction； Brain natriuretic element；Clinical experiment analysis 　　 脑钠肽（BNP）是主要由心室肌细胞分泌的一种神经激素，主要在心室出现容量扩张和压力负荷时分泌。具有利尿、利钠、扩张血管等作用，在心力衰竭中具有极高的诊断和预后评估价值，已成为国际上公认的心力衰竭血浆标志物。本实验通过分析观察AMI时血浆脑钠素的表达水平、左室梗死范围及左室功能的关系,并进一步分析其相关性。 　　1 临床资料与方法 　　1.1 病例选择选自我院于2008年2月-2010年2月期间住院治疗的AMI患者