益气舒心丸对ACS患者CAG术中冠脉血流储备的影响.DOC

益气舒心丸对冠心病PCI术后患者左心室舒张功能的影响和机制研究* 贺青军 陈伟强 罗智敏 庞建萍 欧惠珍 刘照宏 （广东省佛山市中医院心血管内科 佛山528000） 摘要：目的：观察益气舒心丸对冠心病PCI术后患者左心室舒张功能的影响并探讨相关机制。方法：将符合诊断标准的101例冠心病患者随机分为两组。对照组49例予西医常规治疗，不加用任何具有益气或活血作用的中药或中成药；治疗组52例在西医治疗基础上，加用益气舒心丸，治疗6个月。测定治疗前后气虚证、血瘀证积分和一氧化氮（NO）、hs-CRP、内皮素-1（ET-1）等指标的变化。同时，治疗前后行彩色多谱勒超声心动图测定左心室舒张功能等指标变化。结果：治疗组的气虚证、血瘀证积分较治疗前明显降低，优于对照组（P＜0.05）；治疗组的ET-1、hs-CRP较治疗前明显降低，NO较治疗前升高，均优于对照组（P＜0.05）；治疗组的超声心动图测定左心室舒张功能等指标较对照组改善明显，差异有显著统计学意义（P＜0.05）。结论：益气舒心丸可改善冠心病PCI术后患者气虚血瘀状态，改善血管内皮功能，增加舒张期心肌顺应性，从而改善左心室舒张功能。 关键词：PCI术后；气虚证；血瘀证；益气舒心丸；左心室舒张功能；一氧化氮、hs-CRP、内皮素-1 Effect and Mechanism of Yiqishuxin Pill on Left Ventricular Diastolic Function in Patients with Coronary Heart Disease After PCI HE Qing-jun, CHEN Wei-qiang, LUO Zhi-min, PANG Jian-pin, OU Hui-zhen, LIU Zhao-hong (Cardiovascular Internal Medicine, Foshan Hospital of Traditional Chinese Medicine, Foshan, Abstract: Objective: Observe the effect and mechanism of Yiqishuxin pill on left ventricular diastolic function in patients with coronary heart disease after PCI. Method: 101 Cases of ACS were randomly divided into 2 groups according to the diagnostic criteria. The control group (49 cases) received routine treatment of western medicine, without using any chinese medicine with supplementing Qi and activating blood circulation effect. The treatment group (52 cases) on the base of western medicine treatment, plus Yiqishuxin pill, 6 months for a course of treatment. Before and after the treatment, the integral of Qi deficiency and blood stasis syndrome, nitric oxide (NO), hs CRP, endothelin-1 (ET-1) and other indicators were determined. At the same time, left ventricular diastolic function was tested by color Doppler echocardiography. Result: The integral of Qi deficiency and blood stasis syndrome of the treatment group decreased significantly than before treatment, better than the control group (P＜0.05); the ET-1, hs-CRP of the treatment group lower significantly than before treatment, the NO of the treatmengt grou