nCPAP治疗对非急性期CI合并OSAHS患者血液流变学的影响的研究.docVIP

nCPAP治疗对非急性期CI合并OSAHS患者血液流变学的影响的研究 　　【摘要】 目的：研究经鼻持续气道正压通气（nCPAP）治疗对非急性期脑梗死（CI）合并阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者血液流变学影响。方法：选取2013年8月-2015年8月本院收治的非急性期CI合并OSAHS的66例患者作为研究对象，分为治疗组和对照组，每组各33例。对照组给予常规治疗，治疗组加用nCPAP呼吸机治疗，分别于治疗1、3个月后观察血液流变学指标变化。结果：治疗前，两组各血流变指标与平均动脉压比较均无统计学意义（P0.05）；治疗后，治疗组在1、 　　3个月时各血流变指标与平均动脉压均较对照组改善，比较差异均有统计学意义（P0.05）。结论：nCPAP可有效改善非急性期CI合并OSASH患者的血液流变学指标，降低再梗塞发生率，值得临床推广。 　　【关键词】 经鼻持续气道正压通气； 非急性期脑梗死； 阻塞性睡眠呼吸暂停低通气综合征； 血液流变学 　　【Abstract】 Objective：To study the effect of nasal continuous positive airway pressure （nCPAP） on blood rheology in patients with acute cerebral infarction （CI） with obstructive sleep apnea hypopnea syndrome （OSAHS）.Method：66 cases of non acute phase CI with OSAHS from August 2013 to August 2015 in our hospital were selected as the research objects，they were divided into the control group and the treatment group，each group had 33 cases.The control group was given conventional treatment，and the treatment group was treated with nCPAP ventilator，the changes of hemorheology were observed respectively in the treatment of one and three months.Result：Before treatment，the blood rheology indexes and mean arterial pressure of the two groups were not statistically significant（P0.05）.After treatment，the blood rheology indexes and mean arterial pressure of treatment group in one and three months were improved than that of the control group，the differences were statistically significant（P0.05）.Conclusion：nCPAP can effectively improve the hemorheology indexes of patients with non acute phase CI combined with OSASH，and reduce the incidence of re infarction，it is worthy of clinical promotion. 　　【Key words】 Nasal continuous positive airway pressure ventilation； Non acute cerebral infarction； Obstructive sleep apnea hypopnea syndrome； Blood rheology 　　First-author’s address：The Second Affiliated Hospital of Guangdong Medical College，Zhanjiang 524000，China 　　doi：10.3969/j.issn.1674-4985.2016.11.015 　　脑梗死（CI）是内科常见病，梗死后的后遗症严重影响患者的日常活动及生活自理能力，给家庭带来沉重的负担，此类患者