IGF-1在儿童矮小症诊治中的应用(初稿)研究报告.pptxVIP

IGF-1在儿童矮小症诊治中应用的过去、现在与未来安科生物 袁牧2014.9.9The cascade of the growth hormone axisFigure 1The cascade of the growth hormone axis. CNS, central nervous system; GH,growth hormone;GHBP,GH binding protein; GH-S,GH secretagogues; IGF-1,insulin-like growth factor 1; IGFBPs, IGF binding proteins; +, stimulation; –, inhibition.IGF-1基因The IGF-1 gene is on the long arm of chromosome 12q23–23. The human IGF-1 gene consists of six exons, including two leader exons, and has two promoters.Figure 2Type 1 insulin-like growth factor receptor gene and mRNA. Reproduced with permission from WernerIGF binding protei