仿真甲状腺模型评价CT估算甲状腺体积准确性及的影响因素.docVIP

仿真甲状腺模型评价CT估算甲状腺体积准确性及的影响因素 　　【摘要】 目的 探讨CT估算甲状腺体积各种方法的准确性,为甲亢131I治疗剂量计算及手术切除治疗等提供依据。方法 制作实测体积为8.5、12、17、20、24、33、42、66 cm3,中间宽厚,两头尖薄近似体内甲状腺形状的仿真甲状腺模型,共8个;采用西门子Symbia true point SPECT-CT仪行CT扫描及图像重建处理,然后用SPECT/CT仪自带的容积计算软件分别以密度阈值法及层厚3 mm和5 mm手动勾边法估算甲状腺模型体积,并用椭球体公式计算模型体积,均与模型实测体积作配对资料t检验和相关关系分析。结果 甲状腺模型实测体积与密度阈值法及3 mm手动勾边法估算体积无统计学差异(t=0.6605,2.2539;P=0.5301;0.0589)且高度正相关(r=0.998,0.998);而甲状腺模型实测体积与5 mm手动勾边法及椭球体公式法估算体积有统计学差异(t=5.7391,3.7499;P=0.0007,0.0072),且3 mm和5 mm层厚手动勾边法之间也有统计学差异(t=4.0664;P=0.0048)。结论 甲状腺能通过一定密度范围与周围组织完全区分时,CT密度阈值法可较准确、简便地估算甲状腺体积,否侧需采用手动勾边法估算,层厚最好不超过3 mm,操作相对繁锁,但准确性高于5 mm层厚手动勾边及椭球体公式估算体积。 　　【关键词】 仿真模型;计算机体层摄影术,甲状腺体积;阈值;手动勾边;椭球体 　　 　　Study of accuracy and influencing factor of estimating thyroid volume by CT using emulation thyroid gland models 　　 　　MA Tie-kun,CAO Jian-ming,WANG Xue-hong, et al. 　　Department of nuclear medicine, The first affiliated hospital of Kunming Medical College,Kunming 650032,China 　　 　　【Abstract】 Objective To investigate the accuracy of various methods of volume estimation with CT, and to provide accurate volume(mass) of thyroid for radioiodine or surgical therapy in patient with hyperthyroidism.Methods 8 models of emulation thyroid were designed with real volume 8.5,12,17,20,24,33,42,66 cm3 respectively; each of the models was scanned with CT of Siemens symbia true point SPECT-CT, and has reconstructed images.Volume of thyroid models were evaluated by the volume calculation software of SPECT-CT using density threshold and manual tracing(3 mm and 5 mm thickness)respectively, Their volume were estimated with ellipsoid formula as well.Results No statistical difference was found in the estimation volume of density threshold or manual tracing(3 mm thickness) of emulation thyroid model compared to its real volume(t=0.6605,2.2539;p=0.5301,0.0589), and high positive correlation was found between real volume and estimated value from two methods(r=0.9998,0.9998).but between model real volume and estimation volume of manual tr