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Dopamine Receptor
Dopamine receptors are a class of G protein-coupled receptors that
are prominent in the vertebrate central nervous system (CNS). The
neurotransmitter dopamine is the primary endogenous ligand for
dopamine receptors. Dopamine receptors are implicated in many
neurological processes, including motivation, pleasure, cognition,
memory, learning, and fine motor control, as well as modulation of
neuroendocrine signaling. Abnormal dopamine receptor signaling
and dopaminergic nerve function is implicated in several
neuropsychiatric disorders. Thus, dopamine receptors are common
neurologic drug targets; antipsychotics are often dopamine receptor
antagonists while psychostimulants are typically indirect agonists of
dopamine receptors. There are at least five subtypes of dopamine receptors, D1, D2, D3, D4, and D5. The D1 and D5
receptors are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4receptors are
members of the D2-like family.
www.MedChemE 1
Dopamine Receptor Inhibitors Modulators
(±)-Methotrimeprazine D6 Adoprazine
(dl-Methotrimeprazine D6)
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