清华大学有机化学李艳梅-课件(全)第7章.pptVIP

Question 1: Why attacking this site? * Mechanism Less conformation change More conformation change Answer 构象最小改变原理： 环己烷的加成反应（及其它反应）一般按照构象改变最小的方式进行。 larger conformation change less conformation change Energy Reaction process Question 2： Why attacking form a bonds? * 满足反式共平面，过渡态能量低 Answer ? ? Question 3：Try to finish the reaction ! Substituted cyclohexene (B) With HA HA: HX H2SO4 H2O, H2O / H3PO4 有机酸、醇、酚 ＋ H＋ 汞催化下的水合反应： Acid required as a catalyst 与HBr的反应 酸催化下与醇的反应 碳正离子！ CH3CH=CH2 + H+ ? CH3CH2CH2+ + CH3CH+CH3 ? ? ? Markovnikov’s rule: 卤化氢等极性试剂与不