分子生物学3chapter8.ppt

CHAPTER 8: The replication of DNA Meselson and Stahl’s Experiment M. Meselson and F.W. Stahl. 1958. The replication of DNA in Escherichia coli Proc. Natl. Acad. Sci. U.S.A. 44: 671-682. M. Meselson and F. W. Stahl were interested in trying to devise a way to prove or disprove Watson and Cricks model of semi-conservative replication. In 1957, they successfully obtained the experimental proof for the semi-conservative replication of DNA. They did this by inventing a new technique called Density Gradient Centrifugation. Their paper was published in 1958 and ever since, the experiment ha