分子生物学2chapter7.ppt

Bent DNA Binds Nucleosomes Modification of the N-terminal tails of the histones Modification of the histone N-terminal tails alters the function of chromatin Reduce the overall positive charge of histone tails Restrain to form higher order chromatin structure (repressive 30nm fiber) Generates the binding sites for protein Nucleosome assembly Nucleosomes are assembled immediately after DNA replication, and the assembly requires histone chaperones The inheritance of histones after DNA replication Inheritance of parental H3-H4 tetramers facilitates