2008-4种球形栓塞剂对比.pdf

Laboratory Investigations Comparative Study of Four Different Spherical Embolic Particles in an Animal Model: A Morphologic and Histologic Evaluation José I. Bilbao, MD, PhD, Esther de Luis, MD, PhD, José A. García de Jalón, DVD, PhD, Alba de Martino, DVD, María D. Lozano, MD, PhD, Antonio Martínez de la Cuesta, MD, and Bruno Sangro, MD, PhD PURPOSE: To perform a study in a porcine model comparing four different spherical embolic particles in terms of postembolization patency, deformation, and potential for recanalization, with a focus on a relatively new agent— HepaSphere. MATERIALS AND METHODS: Partial embolization of both kidneys was performed in 18 pigs. Nine animals were sacrificed at 48 hours and nine at 4 weeks. In the same animal, the right kidney was embolized with HepaSphere particles (“dry” size, 50–100 m; presumed final size, 200–300 m), and the left kidney was alternatively embolized with EmboSphere (100–300 m), Contour (150–350 m), or Bead Block (150–350 m) particles. The authors analyzed the size, deformation, and number of particles in each vessel, their morphologic characteristics, and recanalization. RESULTS: Particle sizes and deformation (1,096 particles) were as follows: HepaSphere, 225.3 m 67 and 26% 19.7, respectively; EmboSphere, 132.9 m 36 and 18.1% 14.2; Bead Block, 108.1 m 38 and 16.5% 13.9; and Contour, 240.8 m 135 and 55.5% 33. HepaSphere and Bead Block particles were distally located, and EmboSphere and Contour particles were located more proximally. EmboSphere and Bead Block particles were round, HepaSphere particles were round and/or ovoid, and Contour particles had an amorphous aspect. EmboSphere particles had a higher tendency to aggregate. No recanalization was seen with HepaSphere particles, and variable recanalization was observed with the others. CONCLUSIONS: Despite similar initial morphologic characteristics, the p