e4微生物学-南京师范大学英文版PowerPoint课件-(精选·公开·课件).pptVIP

Viral replicase New virions +RNA Proteins(after processing by host and virus-coded proteinases ±RNA Replicative form +RNA （a）positive single-stranded RNA viruses(picornaviruses) RNA Animal virus Reproductive Strategies: RNA-dependent RNA polymerases* (Transcriptases) ＋mRNA New virions ±RNA Proteins RNA-dependent RNA polymerase (Replicase) ±RNA (b) Double-stranded RNA viruses (reoviruses) －RNA ＋mRNA proteins RNN-dependent RNA polymerase (viral replicase) ±RNA Replicative form －RNA RNA-dependent RNA polymerase+ (Transcriptase) New virions （c）Negative single-stranded RNA viruses (paramyxoviruses- mumps and measles;orthomyxoviruses-influenza ＋mRNA New virions RNA-dependent DNA polymerase Reverse transcriptase+ Proteins +RNA Ribonuclease H Component of RT Reverse transcriptase+ +RNA/-DNA Proviral DNA ±DNA -DNA +RNA（virion） Transcription (d )Retroviruses (Rous sarcoma virus,HIV) 4. Assembly and maturation 5.Release(lysis) （1）Eclipse period：it is the period from the virus penetrating host cell to the releasing of virion . Latent prophase or called as eclipse phase means the period during which virus nucleic acid penetrates host cell and assembly the first virion. At that time there are not complete, infectious mature virion. Latency anaphase: During this period, the titer of active virus particles inside cell rises dramatically, but are not release from host cell, which marks the end of latency. （2）Burst phase：During this period, the number of virion increases rapidly with lysis of host cell. （3）Platform phage：It is the period that all of the host cells are lysated and the valence of virus reaches the apogee. Two characteristic data Eclipse period:：it is the minimum course from the penetration of virus to virion release. It is different from different viruses, such as phage’s eclipse period is counted by min