二母颗粒的药学部分研究和初步药效学研究-药剂学专业论文.docx

Abstract Cough is a common kind of clinical diseases, cough frequently would seriously affect patients’ living and working quality. Traditional Chinese Medicine has a deep and sysmatic thinking of the causes of cough. By according to the overall concept and thinking about the different time, place and patient, TCM give different prescriptions and treatments to patients for the syndrome differentiation, which shows an obvious advantage. Ermu Powder, which was made of equal volume of powder of Bulbus Fritillariae Cirrhosae and Rhizoma Anemarrhenae, firstly recorded in Ji Jiu Xian Fang on volume 6, is a classical traditional Chinese medicine prescription that is widely applied to the clinical treatment of heat and sputum stagnated in lung caused cough with curative effect. Because of large surface area of the powder, it is easy to absorb moisture and mildew, which is not so convinent to be stored, carried and used. In order to ensure its quality and suit for its industrialized production, meanwhile to make it more convinent for storage, carrying-about and usage, expand its clinical use, the project intended to change Ermu Powder into Ermu Granule according to physical and chemical properties and functions of the prescription, and also the industrialized principle of “three little, three effect and five convinent”. The preparation parameter was optimized and the granule’s quality standard was studied, and also its fingerprint was studied, which could further value its quality and preparation procedure. Besides, the pharmacodynamic changes before and after its form improvement study were researched, so as to clarify scientificity of form improvement study and rationality of preparation procedure through its preliminary pharmacodynamics studies, which could also provide a reference for controlling its quality comprehensive. Firstly, in pharmaceutical research, extraction process, the kind of pharmaceutic adjuvant and shaping process were studied by using single factor tes