沙利度胺联合MP的方案治疗多发性骨髓瘤临床观察.docVIP

沙利度胺联合MP的方案治疗多发性骨髓瘤临床观察 　　摘要: 目的:观察沙利度胺联合MP方案(MPT)与单用MP方案比较治疗多发性骨髓瘤(MM )的临床疗效及不良反应。方法:治疗组(23例)沙利度胺起始剂量100mg/d,每 1~2周增 加50~100mg,最高剂量为400mg/d并维持治疗,同时联合MP方案化疗,每月1个 疗程。对照 组(22例)单用MP方案化疗。两组在6个疗程后判断疗效。结果:23例治疗组部分缓解14例 (60.9%),进步6例(26.1%),无效 3例(13%),总有效率为87%。22例对照组部分缓解7 例(31.8%),进步 5例(22.7%),无效 10例(45.5%),总有效率54.5%。治疗组疗效比对照 组有显著提高(χ2=6.174,P0.05)。结论:沙利度胺联合MP方案治疗MM较单用MP方案疗效更明显,不良 反应少,耐受性好,给药方便,尤其适用于老年患者。 　　关键词:沙利度胺; MP方案;多发性骨髓瘤 　　中图分类号: R730.53; R733.3 文献标识码: A 文章编号: 1008-2409(2009)05-0826-03 　　 　　Clinical study of the treatment with thalidomide combinated MP protocol on multi p le myeloma/LI Yun∥The First Peoples Hospital of Qingzhou City, Qingzhou 535000 , China 　　Abstract:Objective: To investigate the effect and adverse effect of treatmentwith thalidomide combinated MP protocol on multiple myeloma(MM). Methods: Twent y-three patients with MM in treated group were given thalidomide at 100mg a day at first, and added thalidomide to the maintenance dosage of 400mg a day with th e increasing of 50~100mg in one to two weeks. The chemical therapy of MP protoc ol were given at the same time. The course of treatment lasted for one month. Tw enty-two patients were given the chemical therapy of MP protocol only. The eff e ct and adverse effect of treatment had been evalutated after 6 course of treatme nts. Results: In the treated group, fourteen patients got partial remission, sixpatients were improved, and three patients had no effect. The total effective r ate was 87% in the treated group. In the control group, seven patients got parti al remission, five patients were improved, and ten patients had no effect. The t otal effective rate was 54.5% in the control group. Compared with the controlgr oup, therapeutic effect significantly improved in treated group(χ2 =6.174, P0.05). Conclusion: Effect of treatment with thalidomide combinatedMPprotocol on MM significantly improved than that of the treatment with MP protoco l,and the adverse effect is not increased. 　　Key words:t