药理学专题肿瘤细胞代谢改变与抗肿瘤药物靶点发现邢美春.pptxVIP

The changes in metabolism in tumor and the finding of new targets;higher proliferative rates Metabolic activities in cancer cells are dramatically fast. more nutrient hungry and excrete more waste products resulting in a build-up of metabolites inside the cell and the formation of a more hostile environment outside the cell In order to divide, a cell needs to both increase its size and replicate its DNA — processes that are hugely metabolically demanding and which require large quantities of proteins, lipids and nucleotides, as well as energy in the form of ATP ;Drivers (A and B). The metaboli