生化--郑利民课件 信号转导2－生化课05教学材料.pptVIP

Mechanisms by which hormones, retinoids, and Vit. D regulate gene expression Hormone (H), carried to the target tissue on serum binding prot, diffuses across the PM and binds to its specific receptor protein (Rec) in the nucleus. H binding changes the conformation of Rec; forms homo or heterodimers and binds to specific R regions called hormone response elements (HREs) in the DNA adjacent to specific genes Binding regulates transcription of the adjacent gene(s), increasing or decreasing the rate of mRNA formation. Altered levels of the hormone regulated gene product produce the cellular resp