生化--郑利民课件 信号转导1－生化课08教学材料.pptVIP

asymmetric ion-distribution Resting potential pump and ion leak channels Cl - leak channel Acting potential Acting potential Voltage-gated Na+ channels K+ channels 2.1.1 Ligand-gated ion channel: Binding of some small molecule forces an allosteric transition in protein, open/close channel. acetylcholine (乙酰胆碱) receptor ion channel 2.1.2 Voltage-gated ion channel A charged protein domain moves relative to the membrane in response to a change in transmembrane electrical potential. (voltage-gated Na+， Ca2+，K+ channels) 乙酰胆碱受体离子通道 1 Ach ACh Binding of ACh to R cause conformational change. As