宜宾地区11～136周胎儿心脏轴角度参考值范围的初步探讨.docVIP

宜宾地区11?13+6周胎儿心脏轴角度参考值范围的初步探讨 ［ ］目的探讨宜宾地区孕11?13+6周胎儿心 脏轴角度的参考值范围。方法选取2014年6月?2016 年3月来我院做颈项透明层检测的11?13+6周单胎孕 妇，在四腔心切面上进行胎儿心脏轴角度测量，计 各孕周正常胎儿心脏轴角度参考值范围。结果986例 胎儿1576次测量纳入统计。各孕周胎儿心脏轴角度随 孕周增长而增大。孕11?11+6周的均数为(43.06土 3.82) °，第50百分位数为43.40° ;孕12?12+6周 的均数为(45.82±2.87)°，第50百分位数为45.50° ; 孕1313+6 孕13 13+6 周的均数为(46.99±2.67) 第50 百分位数为47.00° ；不同孕周胎儿心脏轴角度的差?? 有统计学意义。结论宜宾地区孕11 有统计学意义。结论宜宾地区孕11 13+6周胎儿心 脏轴角度参考值范围，其结果对筛查早孕期胎儿先天 性心脏病有所帮助。 ［关键词］早孕期；胎儿；心脏轴；先天性心脏病; 参考值范围 ［ ］R714.5 ［ ］A ［ ］ 2095-0616 (2017)06-16-04 [Abstract] Objective To discussion of reference values of the angle of fetal cardiac axis at 11-13+6 Gestation Weeks in Yinbin area. Methods The cardiac axis， angles were measured at four chamber view in singleton fetuses at 11-13+6 gestation weeks from Jun. 2014 to Mar.2016. The reference values were calculated by statistical methods. Results A tot I e of 1576 measurements from 986 fetuses, were included in this study for analysis. The fetal cardiac axis， angles increased with gestational week. The mean value was (43.06±3.82) °，and the 50th percentile were 43.40° at 11-11+6 week. The mean value was (45.82±2.87)° at 12-12+6 week，and the 50th percentile were 45.50° . The mean value and 50th percentile were (46.99土 2.67) and 47.00° at 13-13+6 week. The differences among three different weeks were statistically significant. Conclusion The reference values of cardiac axis angle at 11-13+6 gestation weeks fetuses in Yibin area is established. It may be valuable on the screening of congenital heart disease in fetuses at 11-13+6 gestation weeks. [Key words] First trimester； Fetal； Cardiac axis； Congenital heart disease； Reference value range 运用心脏轴角度筛查中晚孕期胎儿先天性心脏病 早已得到共识。胎儿心脏轴在中晚孕期的参考值范围 为中轴偏左（45±20） ° [1]。但目前对早孕期胎儿心 脏轴研究却不多，其研究结果也各有不同，国内外尚 无统一的参考值标准。本研究通过大样本测量并统计 宜宾地区孕11?13+6周正常胎儿心脏轴，旨在探讨该 区域该孕龄胎儿心脏轴角度的参考值范围，以期对早 孕期胎儿先天性心脏病的筛查有帮助。 1资料与方法 1.1 一般资料 选取2014年6月?2016年3月来我院做颈项透 明层检测的11?13+6周孕妇。纳入标准：顶臀长在 45?84mm （相当于孕11?13+6周）的单胎。排除标 准：失访或中孕前终止妊娠或流产的胎儿，中晚孕或 出生后诊断有先天性心脏病的胎儿。最终986例胎儿 1576次心