《生理学》 CHAPTER II ENDOCRINE SYSTEM-1培训资料.pptVIP

Cytokind factor receptor(细胞因子受体) This type of receptor is composed of extracellular domain and intracellular domain. The former binds to hormones, which enables the latter to bind soluble tyrosine kinases called Janus kinases(JAK) which phosphorylate intracellular protein and produce the hormone response(Fig 11-5) Guanylyl cyclase receptor: having the enzyme granylyl cyclase as a portion of their intracellular domain. Binding of hormone to the extracellular domain leads to activation of guanylyl cyclase and the formation of cGMP(the second messenger) which initiates activation of cGMP-depe