神经节苷脂治疗早产儿缺氧缺血性脑病56例的的疗效观察.docVIP

神经节苷脂治疗早产儿缺氧缺血性脑病56例的的疗效观察 　　[摘要] 目的 观察神经节苷脂（GM-1）治疗早产儿缺氧缺血性脑病的临床疗效。 方法 将56例确诊为缺氧缺血性脑病而表现为脑室周围白质软化的早产儿随机分为两组，对照组28例给予保暖﹑吸氧﹑供能﹑防治感染﹑维持血糖正常﹑维持水电解质酸碱平衡、对症支持疗法；治疗组28例在上述常规治疗的基础上加用GM-1静脉注射，并定期观察和随访。 结果 治疗组有效率明显优于对照组，治疗组后遗症发生率显著低于对照组，差异有统计学意义（P0.05）。 结论 神经节苷脂是治疗早产儿缺氧缺血后脑室周围白质软化的有效药物。 　　[关键词] 早产儿；缺氧缺血性脑病；脑室周围白质软化；神经节苷脂 　　[中图分类号] R722 [文献标识码] B [文章编号] 1673-9701（2013）32-0087-02 　　Observation of ganglioside（GM-1） on curative effect the 56 patients pretermture infants with hypoxic-ischemic encephalopathy 　　ZHU Yun XIE Guiyang 　　Department of Pediatrics，Yongcheng City Peoples Hospital in Henan Province，Yongcheng 476600，China 　　[Abstract] Objective To observe the clinical effect of ganglioside（GM-1） on preterm infants with hypoxic-ischemic encephalopathy.Methods A total of 56 cases diagnosed with hypoxic-ischemic encephalopathy manifested as periventricular leukomalacia in preterm infants were randomly divided into control group and treatment group.The control group of 28 patients were given the warm，oxygen，energy supply，the prevention and treatment of infections，to maintain normal blood glucose，maintenance of water electrolyte acid-base balance，symptomatic and supportive therapy.Ganglioside was added to the treatment group plus the basis of conventional therapy.The therapeutic effects in the two groups were compared. Results The effective rate in treatment group was significantly higher than that in control group（P0.05）.while the incidence of sequelae was distinctly lower.And the differences were statistically significant （P0.05）. Conclusion Ganglioside is an effective drug for the treatment of preterm infants with hypoxic-ischemic periventricular leukomalacia. 　　[Key words] Preterm infants；Hypoxic-ischemic encephalopathy；Periventricular leukomalacia；Ganglioside 　　新生儿缺氧缺血性脑病是新生儿窒息后的严重并发症，病情重、病死率高，并可产生智力低下﹑癫痫﹑脑性瘫痪和共济失调等永久性神经功能障碍，特别是早产儿，脑瘫的发生率达90‰。早产儿缺氧缺血后脑损伤的病理变化与足月儿不同，其侧脑室周围深部脑白质区有小的﹑白色不透明区或灰白色小结节，常呈对称性分布，此病变称之为脑室周围白质软化（PVL）[1]，是存活早产儿出现神经发育和行为障碍的主要原因。所以，正确判断和积极有效地治疗早产