基因工程抗体以及发展前景.ppt

The Evolution of Therapeutic Antibodies humanization-CDR grafting CDR residues from variable region of a mouse mAb are transferred to human antibody frameworks that have high sequence homology with the mouse counterparts humanization-advantage Murine mAbs have been extensively characterized and have desirable antiviral properties and/or superior fully human mAbs are hardto obtain. This viable approach is the classic and simplest strategy of humanization among many other available strategies, such as grafting specificity determining residues17. The fact that nearly half of all US Food and