补益肝肾法治疗轻型类风湿关节炎的的疗效观察.docVIP

补益肝肾法治疗轻型类风湿关节炎的的疗效观察 　　【摘 要】目的：观察补益肝肾法治疗轻型类风湿关节炎的临床疗效。方法：将120例类风湿关节炎患者随机分为中药组、西药组以及中西药联合组，分别给予三痹汤、甲氨蝶呤、甲氨蝶呤联合三痹汤治疗。观察治疗前后类风湿关节炎患者25羟基维生素D水平变化，并记录治疗前后关节功能相关指标，包括关节肿胀数、压痛数、疼痛程度、健康评价问卷评分、红细胞沉降率、C-反应蛋白。疗程12周，疗程结束后，观察治疗前后患者关节功能指标的变化，比较治疗后各组关节功能改善情况，以达到ACR20、ACR50、ACR70改善标准来评价疗效。结果：西药组及中药组、中西药联合组各项关节指标均得到了缓解，但三组之间比较，差异无统计学意义（P 0.05）；三组患者治疗前后血清25羟基维生素D水平均有改善 　　（P 0.05），中药组及中西药联合组与西药组比较，差异有统计学意义（P 0.05）。结论：血清25羟基维生素D水平变化可能作为类风湿关节炎病情活动的指标之一，补益肝肾法可改善类风湿关节炎患者的血清25羟基维生素D水平。 　　【关键词】 关节炎，类风湿；25羟基维生素D；轻型；补益肝肾 　　To Observe the Curative Effect of the Reinforcing-Liver-to-Benefit-Kidney Method in Treating Mild Rheumatoid Arthritis 　　Zhao Hao，Wang Dan，Li Yu-ming，Qin Li-xin 　　【ABSTRACT】 Objective：To observe the clinical efficacy of the reinforcing-liver-to-benefit-kidney method in treating mild rheumatoid arthritis.Methods：120 cases of RA were randomly divided into the TCM group，the western medicine group and the combined Chinese and western medicine group which were treated respectively with sanbi decoction，MTX and combined MTX and sanbi decoction.Changes of the level of 25 hydroxy vitamin D in RA patients were observed before and after treatment，recording the joint function indexes before and after treatment including the joint swelling，tenderness，pain degree，health assessment questionnaire score，erythrocyte sedimentation rate and C-reactive protein.The course of treatment was 12 weeks，after the course to observe the changes of joint function indexes before and after treatment in patients and the joint function improvements of each group were compared after the treatment in order to achieve the ACR20，ACR50 and ACR70 improvement criteria to evaluate curative effect.Results：Each joint indicator of the three groups had improved，with the difference being not statistically significant（P 0.05）；serum 25 hydroxy vitamin D levels of the three groups before and after treatment were improved（P 0.05），the difference between three groups being statistically significant（P 0.05）.Conclu