补气益精生血方药治疗儿童β地中海贫血随机对照的研究.docVIP

补气益精生血方药治疗儿童β地中海贫血随机对照的研究 　　摘要：目的 评价补气益精生血方药对儿童β地中海贫血的临床疗效。方法 采用随机对照双盲双模拟临床研究，将64例β地中海贫血患儿随机分为中药组和对照组，中药组口服黄芪、党参及龟甲颗粒，对照组口服安慰剂颗粒，疗程12周。观察治疗前后血红蛋白（Hb）、红细胞、平均红细胞体积（MCV）、平均红细胞血红蛋白含量（MCH）、胎儿血红蛋白比例（HbF）等血液学指标及中医四诊症状。结果 疗程结束时，中间型患儿中药组Hb为（9.02±0.98）g/dL，对照组为（7.27±0.95）g/dL，组间比较差异有统计学意义（t=6.729，P=0.003）；中药组HbF较治疗前显著升高（t=-3.341，P=0.011），RBC、MCH及中医四诊症状均有一定改善；中药组总有效率为59.1%（13/21），对照组为4.5%（1/21），中药组显著优于对照组（P0.01）。重型患儿有类似疗效，但逊于中间型患儿。结论 补气益精生血方药治疗儿童β地中海贫血具有较好疗效。 　　关键词：β地中海贫血；中医药疗法；胎儿血红蛋白；儿童 　　DOI：10.3969/j.issn.1005-5304.2015.12.003 　　中图分类号：R272.955.6 文献标识码：A 文章编号：1005-5304（2015）12-0009-05 　　Randomized Controlled Trial of Buqi Yijing Shengxue Therapy for Treatment of Children with β-thalassemia LU Zhuo-ming1， QIAN Xin-hua2， ZHANG Chun-hong1， DU Guang-liang1， ZHU Yong-jian1 （1.Guangzhou Hospital of TCM， Guangzhou 510130， China；2.Nanfang Hospital Affiliated to Southern Medical University ， Guangzhou 510515， China） 　　Abstract：Objective To evaluate the clinical efficacy of Buqi Yijing Shengxue Therapy in children with β-thalassemia. Methods With random controlled double-blind clinical study， 64 children with β-thalassemia were randomly divided into TCM group and control group. The children in TCM group were administrated with oral Astragali Radix， Codonopsis Radix and Tortoise plastron granules， while children in the control group were administrated with oral placebo granules for 12 weeks. The parameters of hematology， such as hemoglobin （Hb）， red blood cell （RBC）， mean corpuscular volume （MCV）， mean corpuscular hemoglobin （MCH）， and fetal hemoglobin （HbF） proportions as well as TCM symptoms were assessed before and after treatment. Results After treatment of 12 weeks， the mean Hb value in children with intermediate β-thalassemia was 9.02 ± 0.98 g/dL in TCM group， as compared with 7.27 ± 0.95 g/dL in control group， with statistical significance （t=6.729， P=0.003）. Comparing initial and last values， mean HbF proportion of children with intermediate β-thalassemia in TCM group ro