补肾壮骨中药抗骨质疏松有效成分及其药理的作用的研究进展.docVIP

补肾壮骨中药抗骨质疏松有效成分及其药理的作用的研究进展 　　[摘要]补肾中药防治骨质疏松症的机制已成为近年来的研究热点，研究发现其具有促进成骨细胞增殖，抑制破骨细胞活性，调节雌激素水平及其受体，促进MSCs成骨并抑制其成脂，调节OPG/RANK/RANKL系统和钙磷代谢及抗氧化等作用。该文从分子和细胞生物学角度对补肾中药抗骨质疏松有效成分及其药理作用机制进行了总结，为揭示其治疗骨质疏松症的机制，深入研究开发补肾壮骨类中药提供参考。 　　[关键词]补肾中药;骨质疏松;发病机制;药理作用机制;研究进展 　　Research progress on anti-osteoporotic active ingredients and pharmacological 　　action mechanism of traditional Chinese kidney-tonifying and 　　bone-strengthening drugs 　　LI Ye1，2， TONG Jielt;supgt;/1lt;/supgt;， ZHOU Yan-jinglt;supgt;/1lt;/supgt;， XU Xiao-yu1* 　　（1.College of Pharmaceutical Sciences， Institute of Chinese Medicine， the Key Subject Constructing 　　Units of Pharmacology of Chinese Materia Medica by the State Administrative Bureau of Traditional Chinese Medicine， 　　Southwest University， Chongqing 400716， China; 2.Department of Clinical Pharmacy of the 　　First People′s Hospital， Yunnan Province， Kunming 650032， China） 　　[Abstract]The therapeutic effects and mechanisms of traditional Chinese kidney-tonifying drugs in treating osteoporosis have become the focus under study. Pharmacological studies have shown that traditional Chinese kidney-tonifying drugs are promoters for the proliferation of osteoblasts， inhibitors for the activity of osteoclasts， regulators for the estrogen level and its receptor， plays important roles in promoting osteogenesis and suppressing adipogenesis of marrow mesenchymal stem cells （MSCs）， modulating the function of OPG/RANK/RANKL system and the metabolism of calcium and phosphorus， as well as antioxidation. The anti-osteoporotic active ingredients and pharmacological action mechanism of traditional Chinese kidney-tonifying drugs are summarized from the perspective of molecular and cell biology in this paper， so as to provide references for the study of their mechanism of anti-osteoporosis and for the development of traditional Chinese kidney-tonifying and bone-strengthening drugs. 　　[Key words]traditional Chinese kidney-tonifying drug; osteoporosis; pathogenesis; pharm