罗格列酮治疗原发性高血压合并2型糖尿病的的疗效观察.docVIP

罗格列酮治疗原发性高血压合并2型糖尿病的的疗效观察 　　[摘要] 目的：探讨罗格列酮治疗原发性高血压合并2型糖尿病的降压疗效。方法：将106例原发性高血压合并2型糖尿病患者随机分为观察组与对照组，每组53例，对照组给予降压药或注射胰岛素控制血糖，加用苯那普利10~20 mg/d；观察组则在对照组的基础上加用罗格列酮15 mg/d，两组12周为1个疗程，并监测血压。结果：观察组总有效率为94.34%，对照组为73.58%，两组相比差异有统计学意义（P0.05）。结论：罗格列酮治疗原发性高血压合并2型糖尿病安全有效，降压作用较强，有明显的肾脏保护作用。 　　[关键词] 原发性高血压；2型糖尿病；罗格列酮；疗效观察 　　[中图分类号] R972[文献标识码]B [文章编号]1674-4721（2011）07（c）-091-02 　　 　　The curative effect of rosiglitazone on the primary hypertension patients with Type 2 diabetes mellitus 　　TAN Baojian, HUANG Guohui 　　Department of Medicine, Taiping Hospital of Qingxin County, Guangdong Province, Qingxin 511853, China 　　[Abstract] Objective: To discuss the curative effect of rosiglitazone on the primary hypertension patients with Type 2 diabetes mellitus. Methods: 106 cases primary hypertension with Type 2 diabetes mellitus patients were randomly divided into observation group and control group, every group for 53 cases, the control group was treated with hypotensor or injecting the insulin to be control of blood glucose, added benazepril 10-20 mg for one. On the basis of the control group, the observation group was treated with rosiglitazone 15 mg for one day. One course period of treatment was 12 weeks, and observed the blood pressure. Results: The total effective rate of the observation group was 94.34 percent, the control group was 73.58 percent, there was statistical significance between the two groups (P0.05). Conclusion: The rosiglitazone on the primary hypertension patients with Type 2 diabetes mellitus is safe, and the hypotensive action is powerful, it can protect the kidney. 　　[Key words] Primary hypertension; Type 2 diabetes mellitus; Rosiglitazone; Curative effect observation 　　 　　原发性高血压不是单纯的血流动力学异常疾病，80%以上存在“代谢紊乱综合征”，故原发性高血压合并2型糖尿病十分常见[1]，二者存在共同发病基础且相互影响，这将增加心血管事件和慢性肾脏的发生率。而两者均是大血管病变的危险因素，心脏性死亡、冠心病、充血性心力衰竭、脑血管病变和微血管病变危险性增加[2]。根据1999年中国高血压病防治指南，对于合并糖尿病的高血压病患者，血压要控制在130/80mmHg以下，在这个血压标准以下可明显减少心血管病的发生率。笔者利用胰岛素增敏剂――罗格列酮治疗原发性高血压合并2型糖尿病，获得满意疗效，现总结分析报道如下： 　　1 资料与方法