非洛地平缓释片治疗高血压患者500例的的疗效观察.docVIP

非洛地平缓释片治疗高血压患者500例的的疗效观察 　　[摘要] 目的：探讨非洛地平缓释片治疗高血压的临床疗效。方法：选择本院2008年3月～2011年3月500例高血压患者，500例患者在参与该研究前先进行一个为期2周的观察期，在观察期间所有患者停用降压药，只服用复方丹参片作为安慰剂，3片/次，3次/d，然后采用口服非洛地平缓释片5 mg，每天早餐后服用，2周后根据患者血压情况调整用药，改为2.5～5.0 mg顿服。治疗期间不使用任何钙离子拮抗剂、血管紧张素转换酶抑制剂和β受体阻滞剂。以4周为1个疗程。结果：1个疗程后500例患者中355例显效，126例有效，19例无效，总有效率为96.2%。治疗过程中5例患者脚踝水肿，7例脸部潮红，所有患者肝肾功能均无明显变化。结论：非洛地平缓释片治疗高血压疗效明显，副作用小，临床上建议进一步使用。 　　[关键词] 非洛地平缓释片；复方丹参片；高血压；疗效 　　[中图分类号] R972+.4 [文献标识码] B [文章编号] 1674-4721（2011）12（b）-084-02 　　 　　Efficacy observation of Felodipine extended-release tablets in the treatment of 500 caseswith hypertension 　　WU Jiehong 　　The Panyu District Central Hoapital of Guanghzou City, Guangdong Province, Guangzhou 511400, China 　　[Abstract] Objective: To investigate the effect of felodipine extended-release tablets in hypertension. Methods: Five hundred cases from March 2008 to March 2011 were selected, before treatment all patients were disabled for the anti-hypertensive drugs for 2 weeks, and were given placebo (Danshen tablets), each 3 tablets, 3 times a day, then used oral felodipine extended release tablets 5 mg, taken daily after breakfast for 2 weeks, and then adjusted the medication plan according to blood pressure. Results: Five hundred patients after a course, 355 cases were markedly effective, 126 cases were effective, 19 cases were ineffective, the total effective rate was 96.2%. Five patients during treatment were ankle edema, 7 cases werefacial flushing, liver and kidney function in all patients had no significant changes. Conclusion: It is valuable about felodipine extended-release tablets in hypertension，the advantage of definite effect，and rapid recovery, it is worthy of further promotion in clinical. 　　[Key words] Felodipine extended-release tablets; Danshen tablets; Hypertension; Clinical curative effect 　　 　　高血压发病率逐年上升，但该病不是单独发生的疾病，经常出现代谢方面的伴随症。高血压的靶器官有心、脑、肾、视网膜等重大脏器，疾病不及时治疗容易造成上述器官的器质性病变，所以对高血压的治疗已经成为目前临床医学讨论的热点话题[1]。非洛地平缓释片是一种新型的二氢毗啶类钙通道阻滞剂，非洛地平缓释片服用简便，一日只要顿服一次，因其缓释片的功能，所以有效浓度维持