《Skin皮肤-英文课件-汕头大学医学院》-课件.ppt

skin the largest organ in the body protect sense regulate temperature Production of Vitamin D * The skin and Skin Regenerative Medicine Kayi Name? Aging skin Clininians Dermatology-----dermatologist Plastic and esthetic surgery------plastic surgeon Keratinocyte fibroblast OBJECTIVE Master skin structure and function epidermis-----keratinization:proliferation/differentiation Acquaitance Anomalies of skin---- common skin diseases Advance Skin regenerative medicine INTRODUCTION epidermis dermis hypodermis Dermis Papillary layer+ Reticular layer 第二节真皮 skin dermis真皮 papillary layer 乳头层 reticular layer 网织层 appendages附属器 hair 毛 sebaceous gland 皮脂腺 sweat gland 汗腺 THE STRUCTURE OF SKIN epidermis表皮 stratum corneum 角质层 stratum lucidum (透明层) stratum granulosum 颗粒层 stratum spinosum 棘层 stratum basale 基底层 nail 指(趾)甲 EPIDERMIS 主要细胞组成 keratinocyte(角质形成细胞 ) non-keratinocyte(非角质形成细胞) differentiation stratum corneum角质层 stratum granulosum颗粒层 stratum lucidum(透明层) stratification stratum basale基底层 stratum spinosum棘层 （一）Epidermal stratification and differentiation PSORIASIS 银屑病 red and white hues of scaly patches appearing on the top first layer of the epidermis (skin). Langerhans cell (郞格汉斯细胞) Langerhans cells are dendritic cells (antigen-presenting immune cells) of the skin and mucosa, and contain large granules called Birbeck granules. They are present in all layers of the epidermis, but are most prominent in the stratum spinosum. In skin infections, the local Langerhans cells take up and process microbial antigens to become fully functional antigen-presenting cells. Langerhans cells derive from the cellular differentiation of monocytes with the marker Gr-1 (also known as Ly-6G/Ly-6C). This differentiation requires stimulation by colony stimulating factor (CSF)-1.6 They are similar in morphology and function to macrophages. Albinos lack an enzyme called tyrosinase. Tyrosinase is required