白藜芦醇对衰老模型小鼠血浆同型半胱氨酸水平氧化应激水平影响的实验-研究.pdfVIP

鼠肝细胞发生变性，体积变小，胞核与胞浆界限模糊，核固缩成三角形或不规则 形；与衰老组相比，干预组小鼠仍有不同程度的肝细胞变性，但变性细胞数量显 著减少；干预II组与干预I组小鼠肝细胞染色结果基本相同。 结 论 l、RSV干预组小鼠血浆Hcy水平低于衰老组，接近基础组； 低于衰老组；接近基础组； 3、RSV干预组小鼠动脉和肝脏损伤较衰老组轻微，接近基础组； 均未出现统计学意义，22．5mg／kg．bw．d更适用于实际应用中。 关键词 白藜芦醇D．半乳糖衰老氧化应激同型半胱氨酸 4 英文论著摘要 Effectofresveratrolon andoxidative homocysteine stressof mice aging Introduction a kindofflavonoid Resveratrol(RSV)is polyphenol formulafor of228．25．RSVis existin C14H1203，molecular weight widely plants，such as and grapes，mulberriespeanuts． thenormalmetabolicofmethionineandthe Homocysteine(Hcy)isproduct cycle intermediateof in lowlevelsinthe important productenergymetabolism．Hcyvery comesfromthediet．Thelevelsof aseriesofadverse body,mainly Hcy，willproduce whichcause reactions，of diseaseofheartheadblood．vesselhaveattractedthemost attention—Thelevelsof areaffected lackoffolic Hcy bymany acid， factors，including vitamin B1 B6，vitamin 2，genetic Freeradicalsinthe hasthe oxidation to body verystrong ability,and easyproduce achainreactiontohurt acidsand resultinthe proteins，nucleic lipids，etc，which aging ofthe hasthe