颅脑损伤急性期凝血与纤溶系统变化的临床意义.pdfVIP

目 录 中文摘要··········································································1 英文摘要··········································································3 正文················································································5 引言················································································5 材料和方法 ·······································································8 结果··············································································12 讨论··············································································20 结论··············································································27 参考文献········································································28 附表··············································································30 缩写词中英文对照表 ·························································31 致谢··············································································32 综述··············································································33 1 万方数据 颅脑损伤急性期凝血及纤溶系统变化的临床意义 中文摘要 【目的】 本研究通过对急性颅脑损伤患者的观察，探讨颅脑损伤后凝血、纤溶功能的 变化趋势及其临床意义，研究其与颅脑损伤严重程度(GCS)及预后(GOS)之间的关 系，并观察血浆 PT，APTT，TT，Fbg，FDP 以及D-二聚体(D-dimer,D-D)含量对 迟发性外伤性颅内血肿(delayed traumatic intracerebral hematoma,DTIH)和 脑内血肿扩大的影响。 【方法】 采用发色底物法和乳胶免疫比浊法对50 例急性颅脑损伤患者于伤后4、8、16、 24、36、48、72 小时分别测定血浆PT，APTT，TT，Fbg，FDP 和D-二聚体含量， 并与20 例正常对照组进行比较；再按伤情轻重、转归及迟发性颅内血肿形成与否 等进行组间比较，应用统计软件SPSS(17.0版)对相关数据进行统计学处理及分析。 【结果】 1.颅脑损伤后各时间点FDP、D-D 测定值与正常对照组相比均有显著性差异(P＜ 0.05)。颅脑损伤后各时间点的APTT、Fbg、PT、TT 测定值与正常对照组相比不 全有显著性差异(P＞0.05)。 2.GCS≤8 分