STAT5、WW和my在非小细胞肺癌中的表达及相关性研究.docVIP

STAT5、WWOX和c-myc在非小细胞肺癌中的表达及相关性研究 王乐朋1 胡福英2 侯莉莉3 王鸿程4 (1都江堰市医疗屮心呼吸内科四川成都611830) (2天门市第一人民医院呼吸内科湖北天门431700) (3河北省胸科医院河北石家庄050041) (4泸州医学院附属医院呼吸内科四川泸州646000) 】FI的：探讨信号转导和转求激活因子-5(Signal transducer and activator of transcripton 5, STAT5)、WW 结构域氧化还原酶基因(WW domain-containing oxidoreductase,WWOX)和 c-myc 蛋白在非小细胞肺癌(non small cell lung cancer, NSCLC)屮的表达及相关性研究。方法：用免疫组化SP法检测40例手术切除的 NSCLC组织和20例正常肺组织屮STAT5、WWOX和c-myc的蛋白表达。结果:STAT5 和c-myc蛋白在NSCLC屮的表达明显高于正常肺组织，而WW0X在NSCLC屮的 表达明显低于正常肺组织(Plt;0.01); STAT5、c-myc表达水平与NSCLC组织学 类型有关,在腺癌组织屮的表达明显高于鱗癌(P8Jt;0.01), WWOX基因的表达与淋 巴结转移相关，有淋巴结转移的表达低于无淋巴结结转移(Plt;0.05); STAT5蛋白 和wwox蛋白在NSCLC组织屮的表达呈负相关(Plt;0.05),而STAT5和c-myc 的表达、WWOX与c-myc的表达无相关性(P〉0.05)。结论：在NSCLC屮存在 STAT5和c-myc的过度表达以及WWOX的失表达,STAT5、c-myc表达水平与NSCLC 组织学类型有关，而WWOX的表达与淋巴结转移相关。在NSCLC的发生机制屮， 提示WWOX可能通过抑制STATs系统，促进细胞凋亡，起到抑癌作用。 关键词】STAT5 WWOX c-myc非小细胞肺癌 屮图分类号】R730.2 】A 】2095-1752 (2013) 11-0108-02 Clinical Significance and expression of STAT5 ,wwox and c-myc in Human non small cell lung cancer WANG le-peng ,HOU li-li,HU fu-ying,WANG hong-cheng Abstract】 Objective:To investigate the expression of STAT5 ,WWOX and c-myc in non small cell lung cancer(NSCLC) and their clinical significance. Method: Forty resected tissue samples from patients with NSCLC and twenty normal lung tissues were subjected to immunohistochemical staining (SP) for STAT5 ,WWOX and c-myc. Results: The expression of STAT5 and c-myc is apparently rised and the expression of wwox is apparently lower in NSCLC than these in normal lung tissues, this has a significance (Plt;O.Ol). The expression of STAT5and c-myc are concerned with NSCLC histological types, in adenocarcinoma was significantly higher than squamous cell carcinoma (P lt;0.01); WWOX gene expression and whether there is lymph node metastasis , with lymph node metastasis NSCLC loss of WWOX gene expression or express a more reduced (Plt;O.O5) . There was a negative correlation between the expressions of STAT5 and WWOX.But no relationship was found between ST