分子生物光子学的进展-生命科学.PDF

20 1 Vol. 20, No. 1 2008 2 Chinese Bulletin of Life Sciences Feb., 2008 1004-0374(2008)01-0014-08 (201800) A An advance in molecular biophotonics WANG Gui-ying*, FU Guo, XU Zhi-zhan (State Key Laboratory of High Field Laser Physics, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800, China) Abstract: Whether on theory or in applications, optical imaging and analysis have gained great progresses with the developments of biological studies and labeling techniques and which exhibits a good prospect. Recently, the biophotonics advances and several new ways of breaking diffraction limit on the optical imaging are described in this paper. In particular, the progresses on the fluorescence resonance energy transfer microscopy and fluorescence correlation spectroscopy, as well as their applications for resolving molecular biologic prob- lem are discussed in detail. Key words: optical imaging and analysis; biophotonics; single molecule detection Abbe Raleigh [1,2] ( fl u or e- 2007-10-29 2007-12-09 973 (2002BC713808)