《新型皮肤渗透促进剂的研究》》-毕业论文.doc

PAGE PAGE 18 摘 要 N-烃基化产物是一类高效渗透促渗剂，可由己内酰胺与卤代烃经N-烃基化反应获得。同时它们也广泛应用于农药、化妆品、印染和制革等多种行业。 本课题研究了以己内酰胺和苄氯为原料、以KF/Al2O3和PTC为催化剂，固液相转移催化合成N-苄基己内酰胺。运用气相色谱-质谱联用确定产物结构，气相色谱分析产品含量。以产物的转化率作为考察指标，采用单因素方法，研究了各种因素如反应原料配比、催化剂用量、反应温度、反应时间等的影响，确定了最佳的工艺条件。其中最佳的工艺条件为：KF/Al2O3用量与原料己内酰胺用量的摩尔比为1：1；己内酰胺和苄氯的用量摩尔比为1：1.5；反应温度为80℃；反应时间为7h。在最佳的工艺条件下转化率高达96.24%。 关键词： N-烃基化反应 N-苄基己内酰胺 渗透剂 相转移催化 Abstract N-alkyl products are a kind of efficient penetration agents which can be synthesized by using caprolactam and halohydrocarbon according to N-alkyl reaction. At the same time, they are also widely used in pesticides, cosmetics, printing and dyeing and tanning and many other industries. The theme involved the synthesis of N-benzyl-caprolactam with caprolactam and benzyl chloride as materials over KF/Al2O3 and PTC by solid-liquid phase transfer catalysis. The resultant was identified by gas chromatography-mass spectrometry and the content of N- benzyl-caprolactam was determined by gas chromatography. By using the method of single-factor, the conversion of resultant as an index, the reaction conditions such as the reactant ratio, the amount of catalyst, the reaction temperature and the reaction time were examined to give the optimum process conditions. The optimum conditions was that the ratio of the KF/AL2O3 amount to the caprolactam amout was 1:1 and the ratio of the caprolactam amount to the benzyl chloride amout was 1:1.5;the reaction temperature of 80℃;the reaction time of 7h.In the optimum process conditions ,the conversion rate was as high as 96.24%. Key words: N-alkyl reaction; N-benzyl-caprolactam; penetration agent ;phase transfer catalysis 目 录 TOC \o 1-3 \h \z \u HYPERLINK \l _Toc232934393 摘 要 PAGEREF _Toc232934393 \h I HYPERLINK \l _Toc232934394 Abstract PAGEREF _Toc232934394 \h II HYPERLINK \l _Toc232934395 目 录 PAGEREF _Toc232934395 \h III HYPERLINK \l _Toc232934396 1 前言 PAGEREF _Toc232934396 \h 1 HYPERLINK \l _Toc232934397 1.1 本课题的目的及意义 PAGEREF _Toc232934397 \h 1