盐酸多奈哌齐片联合补肾益智颗粒治疗阿尔茨海默病临床疗效剖析.docVIP

盐酸多奈哌齐片联合补肾益智颗粒治疗阿尔茨海默病临床疗效剖析 　　[摘要] 目的 探讨盐酸多奈哌齐片联合补肾益智颗粒治疗阿尔茨海默病（AD）临床疗效。 方法 方便选取青岛市城阳区第二人民医院神经内科2014年8月―2016年8月收治的82例AD患者作为研究对象，根据随机数字表法分为两组（每组41例），给予观察组盐酸多奈哌齐片联合补肾益智颗粒治疗，给予对照组盐酸多奈哌齐片治疗，对比两组治疗前后中医症状积分、ADL评分、MMSE评分、ADAS-Cog评分，并统计临床疗效。?Y果 观察组治疗后的ADL评分、MMSE评分、ADAS-Cog评分分别为（25.10±7.92）分、（24.98±4.01）分、（26.82±8.20）分，与对照组比较差异有统计学意义（P0.05）；观察组治疗后的中医症状积分为（10.01±3.12）分，较对照组显著降低（P0.05）；观察组患者的治疗总有效率为80.49%，显著高于对照组的65.85%（P0.05）。结论 盐酸多奈哌齐片联合补肾益智颗粒治疗AD疗效确切，较单独西药治疗可显著提高患者日常生活能力、认知能力和临床疗效。 　　[关键词] 盐酸多奈哌齐片；阿尔茨海默病；补肾益智颗粒 　　[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742（2017）05（c）-0015-03 　　[Abstract] Objective To study the clinical curative effect of donepezil hydrochloride tablets and Bushen Yizhi Granules in treatment of Alzheimers disease. Methods 82 cases of AD patients admitted and treated in our hospital from August 2014 to August 2016 were convenient selected and randomly divided into two groups with 41 cases in each， the observation group were treated with bushen yizhi granules， while the control group were treated with donepezil hydrochloride tablets， and the TCM symptom integral， ADL score， MMSE score and ADAS-Cog score before and after treatment were compared between the two groups， and the clinical curative effect was counted. Results After treatment， the ADL score， MMSE score and ADAS-Cog score in the observation group were respectively （25.10±7.92）scores，（24.98±4.01）scores，（26.82±8.20）， and the differences between the two groups were obvious（P0.05）， after treatment， the TCM symptom integral in the observation group was （10.01±3.12）scores， which was obviously decreased compared with that in the control group（P0.05）， and the total treatment effective rate in the observation group was obviously higher than that in the control group， （80.49% vs 65.85%），（P0.05）. Conclusion The curative effect of donepezil hydrochloride tablets and bushen yizhi granules in treatment of Alzheimers Disease is definite， which can obviously improve the daily living ability， cognitive ability and cl