《联苯双酯滴丸中联苯双酯含量及均匀度分析》-毕业论文（设计）.doc

PAGE 吉林 * * 学院 毕业设计（论文） 题目：联苯双酯滴丸中联苯双酯含量及均匀度分析 姓　　 名 : 系 别、 专 业 : 导 师 姓 名、职 称 : 完 成 时 间 : 联苯双酯滴丸中联苯双酯含量及均匀度分析 摘 要 联苯双酯滴丸为治疗肝炎的降酶药物，有利于肝脏病变的恢复，临床应用多年，降酶疗效肯定。联苯双酯滴丸基质溶解时，体内药物以微细结晶、无定形微粒或分子形式释出，所以溶解快、吸收快、作用快、生物利用度高。实验利用紫外分光光度法测定联苯双酯滴丸中联苯双酯含量，分析联苯双酯含量均匀度。 联苯双酯滴丸中联苯双酯的含量稳定且均匀差异性小，是一种可待继续发展的良好剂型。由于药物服用剂量在制成滴丸后生物利用度得到显著提高，使得准确的临床用药剂量就非常重要。 关键词 联苯双酯 联苯双酯滴丸 含量测定 均匀度 Abstract Bifendate pills for the treatment of hepatitis drug defibrase, conducive to the restoration of the liver lesions, clinical Application many years, defibrase effect certainly. When bifendate pills was dissolved, drugs for in vivo micro-crystalline, amorphous form of particles or molecules released, therefore, fast dissolution, absorption speed, the role of fast, high bioavailability. Treatment of chronic hepatitis virus replication is inhibited, to maintain normal liver function, prevent or delay the process of liver fibrosis, to prevent the occurrence of hepatocellular carcinoma, experimental use of UV spectrophotometer bifendate bifendate pills in content, analysis of content uniformity bifendate. Bifendate bifendate pills in content uniformity and stability of small differences,it is a good question to continue the development of formulations, As the drug dose in the pills are made after the bioavailability significantly improve, that make accurate clinical dosage is very important. KEY WORDS Dimethyl dicarboxylatebiphenyl Bifendate Pills Content Evenness 目 录 TOC \o 1-3 \h \z \u HYPERLINK \l _Toc233016348 摘 要 PAGEREF _Toc233016348 \h I HYPERLINK \l _Toc233016349 Abstract PAGEREF _Toc233016349 \h II HYPERLINK \l _Toc233016350 1 绪 论 PAGEREF _Toc233016350 \h 1 HYPERLINK \l _Toc233016351 1.1 课题背景 PAGEREF _Toc233016351 \h 1 HYPERLINK \l _Toc233016352 1.2 国内外研究情况 PAGEREF _Toc233016352 \h 5 HYPERLINK \l _Toc233016353 1.3 主要研究内容 PAGEREF _Toc233016353 \h 10 HYPERLINK \l _Toc233016354 2 实验材料与方法 PAGEREF _Toc233016354 \h 11 HYPERLINK \l _Toc