丹参酮ⅡA磺酸钠在低氧所致肺动脉高压作用机制的分析.doc

- -- The mechanism of Sodium Tanshinone IIA Sulfonate in the treatment of hypoxic pulmonary hypertension Name: Huang Haile Surpervisor: Li Jing ABSTRACT Background Pulmonary hypertension(PH) is a vascular disease characterized by thickening of pulmonary vessel wall and pulmonary vessel remodeling. Most COPD patients develop Chronic hypoxic pulmonary hypertension (CHPH), chronic cor pulmonale and died ultimately. Plenty of researches showed that changes of intracellular Ca2+ level is greatly related to the contraction and proliferation of pulmonary vascular smooth muscle cells. Among five calc