最新研究microRNA讲义PT课件.pptVIP

MicroRNA The regulation of mRNA Content 1 What is mRNA and its function 2 what is microRNA and it how to control mRNA 3 The function of microRNA The structure of mRNA The structure of mRNA The difference between mRNA and DNA Transcription(转录) Complementary base pairing (碱基互补配对）---The basic theory of transcription The basic group can connect with the corresponding base by the hydrogen bond (氢键) to transfer genetic information The pairing :DNA-DNA A—T C—G DNA-RNA A—U T—A C—G RNA-RNA A—U C—G Transcription Transcription Transcription Translation Codon (密码子）:the codon consist of three bases which can decide the kind of amino acid(氨基酸） Translation Translation Types of RNA What is miRNA miRNA : a kind of small RNA consist of 19~25 ribonucleotide The progress of miRNA development the gene of miRNA pri-miRNA The structure of miRNA The function of miRNA Perfect pairing : this kind of miRNA can cut the mRNA in the special site Incomplete pairing :it can make some position can’t translation miRNA can regulate the mRNA The function of miRNA DNA mRNA protein * * * * * * * * Ribose (核糖） 碱 基 Phosphorus acid (磷酸） A（腺嘌呤） G（鸟嘌呤） C（胞嘧啶） U(尿嘧啶) Basic group （碱基） ribonucleotide (the base of mRNA ) A U G C Ribose connect each other and form the single chain Double chain Single chain Structure Deoxyribonucleotide Ribonucleotide Base unit Phosphoric acid Ribodesose (脱氧核糖) Basic group : A、C、G、T Phosphoric acid Ribose (核糖) Basic group : A、C、 G、 U Component Deoxyribonucleic acid Ribonucleic acid Name DNA RNA A G T A C A A A T T C A T G T T T A A G T A C A A A T U C A U G U U U A mRNA 细胞质基质 核孔 A G T A C A A A T U C A U G U U U A mRNA 细胞质基质 Codon U C A U G A U U A mRNA Condo Cordon U C A U G A U U A A U G 亮氨酸 天冬氨酸 异亮氨酸 pre-miRNA miRNA /~-OH Pri-miRNA Drosha Cl